AN UNBIASED VIEW OF THR777

An Unbiased View of thr777

An Unbiased View of thr777

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The affliction with the classification, provided by the submitter for this submitted (SCV) file. This column also incorporates the influenced position and allele origin of people noticed using this type of variant.

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This sequence change has an effect on codon 777 on the GAA mRNA. It's a 'silent' alter, this means that it doesn't change the encoded amino acid sequence of your GAA protein. This variant also falls at the last nucleotide of exon sixteen, which is part of the consensus splice web-site for this exon. This variant is existing in populace databases (rs375311693, gnomAD 0.03%). This variant has not been documented from the literature in folks influenced with GAA-related ailments.

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This value is calculated by NCBI based upon info from submitters. Go through our policies for calculating the review status. The amount of submissions which lead to this evaluate standing is proven in parentheses.

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The volume of variants in ClinVar for this gene, which include more compact variants within the gene and bigger CNVs that overlap or entirely include the gene.

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Go through our procedures for calculating the assessment position. This column also login thr777 includes a backlink towards the submitter’s assertion standards if supplied, and the gathering method.

Stars stand for the assessment status, or the extent of critique supporting the submitted (SCV) report. This worth is calculated by NCBI depending on data from the submitter.

The worldwide minimal allele frequency calculated via the one thousand Genomes Task. The minimal allele at this locale is indicated in parentheses and may be diverse within the allele represented by this VCV record.

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